12th Sep 2017

New drug helps fight melanoma

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New drug helps fight melanoma
Drew Patchell

Researchers at the Melanoma Institute Australia (MIA) have successfully trialled a new treatment that prevents melanoma from spreading and metastasising.

More than 14,000 Australians will be diagnosed with melanoma this year and around 1800 will likely die. This breakthrough could change the way the cancer is treated in the future and ultimately save lives.

"These two trials have shown that these two different types of therapy can basically stop melanoma in its tracks, prevent it from spreading to become this potentially lethal advanced stage four melanoma," said MIA's medical director Professor Richard Scolyer.

The researchers conducted two trials and both proved successful in preventing the spread of the disease in stage three melanoma patients whose tumours had been surgically removed. The first trial involved participants taking immunotherapy drugs that reboot the immune system to attack the melanoma cells.



"Twelve months of these tablet therapies decreased the chance of the melanoma coming back  – compared to doing nothing – by 53 per cent," said Professor Georgina Long, the institute's conjoint medical director.

"So if your chance of your melanoma coming back and killing you is 50 per cent and I say you take these drugs for 12 months and I'll reduce that to 25 per cent or less, that's huge," she continued.

"What's more, because that trial is more mature, we also have a survival benefit and the decrease in the improvement in survival is we decrease your risk of death from melanoma by 43 per cent."

During the second trial, participants received a combination of targeted therapies all of which blocked the action of a particular gene that is a known driver for melanoma. 

According to Professor Scolyer, the second trial (known as CheckMate) also reduced the rate of the disease returning by around 35 per cent, but it was too soon to tell if the drug improved overall survival rates.

"They only work locally, but don't prevent the disease if it's already spread elsewhere," he said.

What do you think? Are you hopeful for the future in seeing Australian researchers make such a powerful discovery and leap forward in the treatment of melanoma?

Read more at abc.net.au

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COMMENTS

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the_Albert
12th Sep 2017
11:35am
My father died of melanoma, and so far as I know he had no treatment at all after excision of the primary site (on his back) and no regular check-ups. Presumably nothing was available, though I wonder whether chemo and/or radio therapy should've been given rather than merely assume that the surgery had got it all. By the time he got crook again the thing had metastasized and nothing further could be done and he died within two months of diagnosis. If these new therapies had been available he might've lived for many more years.
KSS
12th Sep 2017
1:38pm
Best not to get melanoma in the first place!
MICK
12th Sep 2017
3:08pm
Tell that to an Australian. Like telling an Italian not to eat spaghetti.
Think I'll get checked again. Missed last year and spend too much time working in the garden.
Certainly better not to get the condition but medicine is making inroads with a number of ailments.


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