Do you want to live to 120?

Human trials for a drug that may slow the ageing process will start next year.

Do you want to live to 120?

Scientists believe a drug that has been used to treat type 2 diabetes since the 1940s could also be used to slow the ageing process and effectively reduce occurrences of other age-related illness and disease.

Metaformin is currently used to control blood sugar levels, but has also proven to increase the lifespan of diabetic patients by an average of eight years.

Many scientists believe the drug could also reduce the occurrence of Alzheimer’s and Parkinson’s, as well as other illness and disease associated with ageing.

“If you target an ageing process and you slow down ageing then you slow down all the diseases and pathology of ageing as well,” said study advisor Professor Gordon Lithgow of the Buck Institute for Research on Ageing in California.

Scientists already know that Metaformin can extend the life of animals. Preliminary tests have seen them age slower and stay healthier – even increasing a mouse’s life span by around 40 per cent, as well as increasing its bone strength.

A new clinical trial called Targeting Ageing with Metaformin (TAME) has been approved by the Food and Drug Administration in America to see if the same results might apply to humans. The human trial phase will commence in 2016, with 3000 volunteers aged 70 – 80 years, who have or are at risk of dementia, cancer and heart disease, taking part. Should the trial be successful, it is estimated that a 70-year-old will feel as biologically healthy as a 50-year-old, and that it may be possible to help people live healthily for up to 120 years.

It is also hoped that, by slowing down the ageing process, the drug could be used to treat kidney disease, polycystic ovary syndrome, gestational diabetes, loss of muscle tone, dizziness, falls, dementia, loss of eyesight and cancer.

“Enough advancements in ageing science have been made to lead us to believe it’s plausible, it’s possible, it’s been done for other species and there is every reason to believe it could be done in us,” said Professor Lithgow.

According to the Australian Bureau of Statistics (ABS), life expectancy for Australians born in 2014 is 80.3-years-old for men and 84.4 for women, but scientists believe that, with the use of Metaformin, these estimates could be increased by almost 50 per cent.

If trails are successful, it could be the most important medical intervention in the modern era. Professor Lithgow believes that the drug could take the form of a ‘vaccine’ used to slow the effects of ageing.

Early results of the trial will be revealed in five years.

Read more at The Telegraph

Does the news of this drug excite you? Would you participate in such a trial? Would you like to live for 120 years? What type of issues do you think would be associated with living so long? 





    COMMENTS

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    3rd Dec 2015
    10:00am
    Bit of a worry for the Federal Government. They might have to move quickly to raise the retirement age further, or maybe declare those who take the drug ineligible for the aged pension?
    Sen.Cit.90
    3rd Dec 2015
    10:14am
    The extension of life is not appealing, but this paragraph is:
    It is also hoped that, by slowing down the ageing process, the drug could be used to treat kidney disease, polycystic ovary syndrome, gestational diabetes, loss of muscle tone, dizziness, falls, dementia, loss of eyesight and cancer.
    Sen.Cit.90
    3rd Dec 2015
    2:21pm
    Just realised I already take 'diabex XR' each containing metformin hydrochloride 1000mg.
    The write up spells Metaformin! is this a spelling error or is 'Metformin and Metaformin' one and the same?
    Inatrance
    3rd Dec 2015
    10:28am
    Why would I even contemplate living to this age of 120, It will be another 60 years before I get there and by then this world will be a burnt out filthy putrid place to try and eke out any sort of life. Let me go early so I don't witness our own destruction.
    Anonymous
    3rd Dec 2015
    10:49am
    Agree completely, Inatrance. I dread to think what kind of world we will live in 30 years from now, and I certainly don't want to be here 50 years from now.
    MILA
    3rd Dec 2015
    11:03am
    Hi Rainey: AGREE WITH YOU 100% !
    Rod63
    3rd Dec 2015
    3:54pm
    Dear oh dear - what a pessimistic lot you are.
    MILA
    3rd Dec 2015
    11:02am
    so, let us start singing FOREVER YOUNG (ho ho ho)
    Precious 1
    3rd Dec 2015
    11:21am
    Absolutely I love my life and would love to be considered.


    Go girl go.


    Make history...cheer up and imagine all the family you would have and friends lolol
    Adrianus
    3rd Dec 2015
    11:11am
    Many posters will not take it for fear of validating Joe Hockey's statement.
    Camira
    3rd Dec 2015
    11:25am
    No, I don't want to live to that age, it's too old.
    Living Well
    3rd Dec 2015
    12:10pm
    OH Boy, not only do we have to wait a probable 5 years but we will be offered a drug complete with all the inherent NEGATIVE side effects. What is amazing is that a Non Invasive technology is already being used in hospitals in Europe and elsewhere overseas with great results. This technology is low cost, easy to use, safe, has NO harmful side effects and is extremely effective. While I and 100,000s of others overseas already receive the benefits of this new technology I guess Australia in general may be waiting many years for this far improved quality of life. People using this technology create far less drain on the medical system and because are happier and healthier can work longer and rely less on an Age Pension.
    Adrianus
    3rd Dec 2015
    12:16pm
    I'm going to need more super!
    Ageing but not getting old
    3rd Dec 2015
    6:12pm
    Living Well: So; WHAT IS this non-invasive technology people in European Hospitals (& elsewhere), that's inexpensive with no harmful side effects, but works really well? Hope you're not just jokingly referring to exercise or 'eating healthily' etc; that would be cruel..
    Adrianus
    4th Dec 2015
    11:54am
    Ageing, HGH has been known to slow down ageing and I suppose allow 75 year olds to continue being action heroes.
    CindyLou
    4th Dec 2015
    3:40pm
    Me thinks that 'Living well' has something to flog....
    BEWARE
    Adrianus
    4th Dec 2015
    4:18pm
    CindyLou, well done. You recognised the "big boast" with the aim of arousing curiosity.
    BB1
    3rd Dec 2015
    1:01pm
    Definitely not. But with extending age to 120, it may mean that the elderly will have to wait for the Pension until 80 or 90. That's the frightening part.
    Chris B T
    3rd Dec 2015
    1:27pm
    Would Prof Lithgo be John Lithgo's alter ego. (3rd Rock From The Sun)
    One way trip to Mars would be more likely.
    ;-)
    Patriot
    3rd Dec 2015
    1:58pm
    It is very sad to observe how many people refuse to take "Ownership" of the current mess Australia & this planet as a whole is in.
    Let's not forget that we "Allowed" this mess to be created whilst we were doing "other things". "It happened on Our Watch!!!".
    We now MUST "Own Up" and reverse this abominable condition for the sake of our (grand)children & the Planet!
    Life experience
    3rd Dec 2015
    2:12pm
    I want some NOW.
    Polly Esther
    3rd Dec 2015
    2:57pm
    Marvellous, there are enough 'zombies' getting about now, of all ages, I think.
    'Zombies' driving cars, frightening!!!!
    pauline
    4th Dec 2015
    5:02pm
    Yes, Polly, it is scary, isn't it. I cannot think of anything worse than the walking dead taking up limited space and consuming limited resources of our planet. I think it is selfish to want to hang in there when we've already had our day and the time has come for us to make way for other humans to have their turn.
    Rod63
    3rd Dec 2015
    3:57pm
    As long as I was healthy, happy and had my mind still, yes - I would love to live until I was 120.
    Jennie
    3rd Dec 2015
    4:22pm
    In an overpopulated world living to 120 is totally unethical and unacceptable.
    Strummer
    4th Dec 2015
    7:57am
    Completely agree Jennie. The greatest problem facing the human race is over-population of this planet.
    loraines
    4th Dec 2015
    11:33am
    So let's all die young and save the planet?? Not me, sister.
    Adrianus
    4th Dec 2015
    11:50am
    Yes I agree loraines, let's stick around see if there is something to contribute.
    pauline
    4th Dec 2015
    1:10pm
    Not good for the planet if we all live to 120 consuming limited resources .


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