Drinkable ‘cocktail’ may prevent Alzheimer’s disease

Yale University researchers may have created a drinkable cure for Alzheimer’s.

Drinkable ‘cocktail’ may prevent Alzheimer’s disease

Yale University researchers may have stumbled across a drinkable cure for Alzheimer’s, having identified a cocktail of molecules that interferes with the disease and possibly even restores memories.

In a report on the journal Cell Reports, Yale researchers claim they have created a cocktail of designer molecules that interferes with the crucial first step of Alzheimer’s. According to a Yale University report, the “binding of amyloid beta peptides to prion proteins triggers a cascade of devasting events in the progression of Alzheimer’s – accumulation of plaques, a destructive immune system response, and damage to synapses”.

“We wanted to find molecules that might have a therapeutic effect on this network,” said senior author and director of Yale University’s Alzheimer’s research department, Stephen Strittmatter.

While attempting to identify molecules that might interfere with the early stages of Alzheimer’s, Prof. Strittmatter and research scientist Erik Gunther found that an old antibiotic that looked like a promising candidate but was only active after decomposing to form a polymer, some of which were able to pass through the blood-brain barrier.

They then dissolved this compound and tested it on mice with conditions that simulate Alzheimer’s. After delivery, they found that synapses in mice brains were repaired and lost memories were recovered.

In an article on the New York Post, Dr David Reynolds from Alzheimer’s Research UK said: “The researchers showed that this experimental drug is able to improve memory symptoms and restore vital nerve cell connections in mice bred to have features of Alzheimer’s.”

“These promising early results will need to be reproduced in further experiments that also establish the drug’s safety profile before it can enter clinical trials to see whether it is effective in people with Alzheimer’s disease.

“With no new drug treatment for dementia in over 15 years, promising early findings like this serve as a positive reminder that research is making progress towards breakthroughs that will change lives.”

In the same article, Dr James Pickett from Alzheimer’s Society said: “We are looking into whether diabetes and arthritis treatments could benefit people with dementia, so it’s fascinating that something based on antibiotics could too.”

Clinical trials for Alzheimer’s disease will commence once the compound is verified as non-toxic.

Would you take part in trials for Alzheimer’s research? Does the idea of an anti-dementia drinkable cocktail appeal to you?

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    COMMENTS

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    zoomer
    7th Jan 2019
    11:40am
    Yes I would be very interested in being involved in this study. My mother had dementia and I sometimes worry about my own memory. I am also a type 2 diabetic so that increases my level of worry.
    Regards Lois Ely
    KB
    7th Jan 2019
    11:44am
    Yes. I t think that relations who have parents with dementia or the other disease should be encouraged to try the cocktail. Anything to slow down or prevent theses hideous diseases is a good thing
    Linda
    7th Jan 2019
    12:13pm
    Yes, I think my partner would be prepared to try it.
    AJ
    7th Jan 2019
    12:16pm
    Yes I would be interested in being involved in this study
    Tzuki
    7th Jan 2019
    12:46pm
    I would definitely want to try it! My father just passed away from dementie. How do you get to participate?
    Eliza
    7th Jan 2019
    1:24pm
    Yes I would be interested in participating in the research ...
    As much as possible should be done to find a cure for this horrible debilitating disease.
    At the very least we must find an effective treatment ...
    The brain is just another organ of our body, one of the most important of all and we know so little about it compared with other major organs.
    So count me in.
    PlanB
    7th Jan 2019
    2:58pm
    I would like to know what the drink was 1st
    Cheezil61
    7th Jan 2019
    3:48pm
    Interesting, would like more info on this!
    SANGA
    7th Jan 2019
    4:21pm
    LOCK ME IN EDDIE,any Trial is Better Then Nothing at All. GRANT SAINSBURY
    Eliza
    7th Jan 2019
    5:43pm
    ‘Clinical trials for Alzheimer’s disease will commence once the compound is verified as non-toxic.’
    Any research such as this requires rigorous testing for toxicity before any testing on humans.
    DM
    7th Jan 2019
    7:04pm
    Most definitely be interested and I know others who would be as well
    vinradio
    7th Jan 2019
    7:13pm
    I'd be interested, as my older sister and mother both had dementia.
    musicveg
    7th Jan 2019
    10:40pm
    No not interested, only interested in what causes it and how to prevent it. Funny how they are only doing research on what drug they can produce, and who knows what the side effects will be.
    GeorgeM
    7th Jan 2019
    10:55pm
    Exactly my thoughts - drug companies invest in research only for cures, also playing down side effects, whereas prevention is always the best approach. The proportion of prevention research funding and also publicity for known causes is very limited - something research & Govt bodies need to focus on much harder.
    OnlyDaughter
    7th Jan 2019
    11:39pm
    Whilst I don’t have dementia, or the early signs of cognitive decline as yet, my Mother does and she is a nightmare. So, yes, i’d volunteer because I would hate to think I could cause the trouble and devastation that my Mother has to my family.
    Geminiwoman
    8th Jan 2019
    9:35am
    Yes, yes and yes again. I would certainly try almost anything that would potentially stave off this nasty disease.
    Mamacrystal
    8th Jan 2019
    8:12pm
    Yes, of course. However you would probably have to be very lucky to "be in the right spot at the right time" to get chosen to be involved.
    Nose Hair Bob
    9th Jan 2019
    10:41am
    No.
    Rotoha
    11th Jan 2019
    11:44am
    The cost to families and the country from this disease is astronomical. Watching people lose their memories, fail to recognize their family and much more is heart breaking...as a nurse and a child of parents who both suffered it. I would be definitely be interested in taking part in the trials, but as yet don't have symptoms, well, not that I am aware of anyway.
    Alexia
    6th May 2019
    2:57pm
    Any development to prevent or cure dementia is worthwhile, I hope this one proves o be effective.