Healthy life extension
There is a lot of research being done into healthy life extension, a lot of it being funded by Silicon Valley companies such as Google.
Their aim is to have Old Age treated as a disease and to tackle the underlying cause, not the one at a time diseases that are prevalent in old age such as dementia or cancer.
The past century saw a doubling in lifespan but this was brought about through reduction in infant mortatilty and better diet.
The only known method of increasing life span is diet. Through a calorie restricted diet.
For the first time in history the FDA has approved the trial of a drug to taclkle the disease of ageing.
The drug metamofin has been around for many years and has been used to treat diabetics.
The drug, like asprin, is so inexpensive to make (from the lily family) that no drug company will investigate it.
Therefore research is being funded by non profit organisations one which I belong to has issued the below report.
I am taking metamorfin and eating a CRD myself.
The world’s first anti-ageing drug will be tested on humans next year in trials which could see diseases like Alzheimer’s and Parkinson’s consigned to distant memory.
Scientists now believe that it is possible to actually stop people growing old as quickly and help them live in good health well into their 110s and 120s.
Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go ahead for a trial to see if the same effects can be replicated in humans.
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“This would be the most important medical intervention in the modern era, an ability to slow ageing”Dr Jay Olshansky, University of Illinois ChicagoADVERTISING
If successful it will mean that a person in their 70s would be as biologically healthy as a 50 year old. It could usher in a new era of ‘geroscience’ where doctors would no longer fight individual conditions like cancer, diabetes and dementia, but instead treat the underlying mechanism – ageing.
Scottish ageing expert Professor Gordon Lithgow of the Buck Institute for Research on Ageing in California, is one of the study advisors.
“If you target an ageing process and you slow down ageing then you slow down all the diseases and pathology of ageing as well,” he said “That’s revolutionary. That’s never happened before.
“I have been doing research into ageing for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-ageing drug would have been though inconceivable.
“But there is every reason to believe it’s possible. The future is taking the biology that we’ve now developed and applying it to humans. 20 years ago ageing was a biological mystery. Now we are starting to understand what is going on.”
Growing older does not have to bring ill health and frailty CREDIT: ALAMY
Ageing is not an inevitable part of life because all cells contain a DNA blueprint which could keep a body functioning correctly forever. Some marine creatures do not age at all.
However over our lifetime billions of cell divisions must occur to keep our bodies functioning correctly and the more times cells divide the more errors creep into the process. As cell problems grow, the body can no longer repaid damage. In the case of cancer, cells no longer have the ability to get rid of mutations, and tumours grow. In Alzheimer’s the brain stops clearing out sticky plaques, and dementia develops.
Scientists think the best candidate for an anti-ageing drug is metformin, the world’s most widely used diabetes drug which costs just 10p a day. Metformin increases the number of oxygen molecules released into a cell, which appears to boost robustness and longevity.
When Belgian researchers tested metformin on the tiny roundworm C.elegans the worms not only aged slower, but they also stayed healthier longer. They did not slow down or develop wrinkles. Mice treated withmetformin increased their lifespan by nearly 40 per cent and their bones were also stronger. Last year Cardiff University found that when patients with diabetes were given the drug metformin they in fact lived longer than others without the condition, even though they should have died eight years earlier on average.
The new clinical trial called Targeting Aging with Metformin, or TAME, is scheduled to begin in the US next winter. Scientists from a range of institutions are currently raising funds and recruiting 3,000 70 to 80 year olds who have, or are risk of, cancer, heart disease and dementia. They are hoping to show that drug slows the ageing process and stops disease.
Outlining the new study on the National Geographic documentary Breakthrough: The Age of Ageing, Dr Jay Olshansky, of the University of Illinois Chicago, said: “If we can slow ageing in humans, even by just a little bit it would be monumental. People could be older, and feel young.
“Enough advancements in ageing science have been made to lead us to believe it’s plausible, it’s possible, it’s been done for other species and there is every reason to believe it could be done in us.
“This would be the most important medical intervention in the modern era, an ability to slow ageing.”
Metformin could hold the key to ageing well
A baby girl born today is now expected to life to an average age of 82.8 years and a boy to 78.8 years, according to the Office for National Statistics. But if the results seen in animals are reproduced in humans, lifespan could increase by nearly 50 per cent.
Professor Lithgow believes that, in the future, young people may be given a type of ageing ‘vaccine’ to slow down ageing. He believes it could have a far bigger impact on extending population lifespan that finding a cure for cancer.
“If we were to cure all cancers it would only raise life expectancy by around three years, because something else is coming behind the cancer, but if we could slow down the ageing process you could dramatically improve how long people can live,” he said.
“We know that it is possible for handfuls of people to live to very old age and still be physically and socially active, so clearly they carry some kind of protection in their bodies. They are essentially not ageing as quickly. If we can harness that, then everyone can achieve those lifespans.”
Yet scientists have faced an uphill battle to get trial approval because there are so many spurious claims of ‘anti-ageing’ technologies and therapies on the market.
Stephanie Lederman, executive director of the American Federation for Aging Research in New York, who is also involved in the trial added: “The perception is that we are all looking for a fountain of youth.
“We want to avoid that; what we’re trying to do is increase health span, not look for eternal life.”
However if their trial performs as promised, experts say slowing ageing would be a ‘public health revolution.’
Dr Robert Temple, deputy director of the FDA said: “Their hope is that a wide variety of age related problems, loss of muscle tone, dizziness, falls, dementia, loss of eyesight, all of those things.
“That would be something never done before. If you really are doing something to alter ageing the population of interest is everybody. It surely would be revolutionary if they can bring it off.”
Dr Simon Melov of the Buck Institute for Ageing Research added: “You’re talking about developing a therapy for a biological phenomenon which is universal and gives rise to all of these diseases. And if you’ve got a therapy for this thing, these diseases just go away.”
Telwgraph London
Breakthrough: The Age of Ageing airs on Sunday 10pm on the National Geographic Channel.
Here are some tips Pete for your topic "healthy life extension"
1) Get out in natureYou probably seriously underestimate how important this is. (Actually, there’s research that says you do.) Being in nature reduces stress, makes you more creative, improves your memory and may even make you a better person.
2) ExerciseWe all know how important this is, but few people do it consistently. Other than health benefits too numerous to mention, exercise makes you smarter, happier, improves sleep, increases libido and makes you feel better about your body. A Harvard study that has tracked a group of men for more than 70 years identified it as one of the secrets to a good life.
The Brief NewsletterSign up to receive the top stories you need to know right now. View SampleSIGN UP NOW3) Spend time with friends and familyHarvard happiness expert Daniel Gilbert identified this as one of the biggest sources of happiness in our lives. Relationships are worth more than you think (approximately an extra $131,232 a year.) Not feeling socially connected can make you stupider and kill you. Loneliness can lead to heart attack, stroke and diabetes. The longest lived people on the planet all place a strong emphasis on social engagement and good relationships are more important to a long life than even exercise. Friends are key to improving your life. Share good news and enthusiatically respond when others share good news with you to improve your relationships. Want to instantly be happier? Do something kind for them.
4) Express gratitudeIt will improve your relationships.
It can make you a better person.
It can make life better for everyone around you.
Play Video5) MeditateMeditation can increase happiness, meaning in life, social support and attention span while reducing anger, anxiety, depression and fatigue. Along similar lines, prayer can make you feel better — even if you’re not religious.
6) Get enough sleepYou can’t cheat yourself on sleep and not have it affect you. Being tired actually makes it harder to be happy. Lack of sleep = more likely to get sick. “Sleeping on it” does improve decision making. Lack of sleep can make you more likely to behave unethically. There is such a thing as beauty sleep.
Naps are great too. Naps increase alertness and performance on the job,enhance learning ability and purge negative emotions while enhancing positive ones. Here’s how to improve your naps.
7) Challenge yourselfLearning another language can keep your mind sharp. Music lessons increase intelligence. Challenging your beliefs strengthens your mind. Increasing willpower just takes a little effort each day and it’s more responsible for your success than IQ. Not getting an education or taking advantage of opportunities are two of the things people look back on their lives and regret the most.
8) LaughPeople who use humor to cope with stress have better immune systems, reduced risk of heart attack and stroke, experience less pain during dental work and live longer. Laughter should be like a daily vitamin. Just reminiscing about funny moments can improve your relationship. Humor has many benefits.
9) Touch someone (Not yourself)Touching can reduce stress, improve team performance, and help you be persuasive. Hugs make you happier. Sex may help prevent heart attacks and cancer, improve your immune system and extend your life.
10) Be optimisticOptimism can make you healthier, happier and extend your life. The Army teaches it in order to increase mental toughness in soldiers. Being overconfidentimproves performance.
Anti-Aging Human Study on Metformin Wins FDA Approval March 2016
By Judy Stevens
News Reports around World Describe Multiple BenefitsThe media has caught up to the potential health benefits of metformin, something our long-term supporters discovered long ago.
What caught the media’s attention was the FDA’s approval of the first human study to see if metformin can protect against the multiple diseases of aging.
Prominent headlines around the world proclaimed:
“New Anti-Aging Drug Could Extend Human Life Span to 120 Years”Metformin of course is not a new drug. It was approved in England in 1957 and made available to type II diabetics around the world shortly thereafter. It took the FDA a staggering 37 years to approve it in the United States.
Here are some accurate quotes from worldwide news sources:
“Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go-ahead for a trial to see if the same effects can be replicated in humans.”
“I have been doing research into aging for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-aging drug would have been thought inconceivable…20 years ago aging was a biological mystery. Now we are starting to understand what is going on.”
“Scientists think the best candidate for an anti-aging drug is metformin, the world’s most widely used diabetes drug, which costs just 10p [15 cents] a day. Metformin increases the number of oxygen molecules released into a cell, which appears to boost robustness and longevity.”
“If we can slow aging in humans, even by just a little bit, it would be monumental. People could be older, and feel young.”
“This would be the most important medical intervention in the modern era, an ability to slow aging.”
Even the venerable Dr. Robert Temple, deputy director at the FDA, chimed in by stating:
“Their hope is that a wide variety of age-related problems, loss of muscle tone, dizziness, falls, dementia, loss of eyesight, all of those things [sic]. That would be something never done before. If you really are doing something to alter aging, the population of interest is everybody. It surely would be revolutionary if they can bring it off.”
Dr. Simon Melov of the Buck Institute for Research on Aging added:
“You’re talking about developing a therapy for a biological phenomenon which is universal and gives rise to all of these diseases. And if you’ve got a therapy for this thing, these diseases just go away.”
Life Extension® Has Championed Metformin for 20 YearsLife Extension® magazine listed metformin as one of many important offshore medications back in 1995. And now, 20 years later, even the FDA concurs that metformin has potential to delay the onset of degenerative diseases.
But contrary to news headlines, metformin will not enable humans to live to 120 years of age all by itself. What it may do is allow humans to age better today—thereby staving off degenerative diseases long enough for age-reversal breakthroughs to become clinically available.
Metformin’s Primary Anti-Aging MechanismMetformin enhances the activity of an enzyme found within our cells called adenosine monophosphate-activated protein kinase—or AMPK for short. AMPK activation helps mimic the beneficial effects of calorie restriction, the best documented method of slowing and reversing biomarkers of human aging.
We at Life Extension® have long endorsed AMPK activation as a method of slowing biological aging. We advocate that our supporters utilize some proven method to increase their cellular AMPK activity, which could add substantial healthy years to the average life span.
How to Boost Your AMPK Today!We do not want you to age prematurely, waiting years for the results of the new FDA-approved human study. That’s why we recommend you initiate steps now to boost healthy AMPK activity today.
One of the benefits of practicing consistent calorie restriction is a substantial increase in AMPK activity as cells go into a semi-starvation mode and increase their survival efficiency.
People under age 60 who regularly/vigorously exercise boost their AMPK levels. This may be the mechanism by which exercise markedly lowers cancer risk. As people age past 60, exercise may not adequately boost AMPK enzyme activity.
If you’re presently taking 1,000 to 2,550 mg of metformin daily, you don’t have to do anything, simply enjoy this drug’s anti-aging benefits. But if you cannot acquire a prescription for metformin, or cannot tolerate it due to digestive issues, there are nutrient formulas that have been shown to significantly boost AMPK activity.
On the next page is a reprint of one of many articles appearing around the world that report on the first clinical trial to see if a drug can slow aging and enable people to live longer.
While the headline of this (and many other articles) is exaggerated, the quotes from mainstream researchers accurately reflect what metformin might demonstrate in this first clinical study.
We at Life Extension® will stay abreast of this study to ascertain how close its design and implementation come to our long-standing recommendations on the use of this AMPK-activating medication.
If you have any questions on the scientific content of this article, please call a Life Extension®Wellness Specialist at 1-866-864-3027.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.