10th Jan 2018
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The drug you may already take that could prevent dementia
Author: Ben Hocking
Diabetes drug reverses memory loss

A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice.

The research, published in Brain Research, could bring substantial improvements in the treatment of Alzheimer's disease through the use of a drug originally created to treat type 2 diabetes.

Lead researcher Professor Christian Holscher of Lancaster University in the UK said the novel treatment “holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer’s disease”.

Dementia is the second leading cause of death among Australians, and the single greatest cause of disability in older Australians (aged 65 years or older). There are more than 413,106 Australians currently living with dementia.

Dr Doug Brown, Director of Research and Development at Alzheimer’s Society, said: “With no new treatments in nearly 15 years, we need to find new ways of tackling Alzheimer’s. It’s imperative that we explore whether drugs developed to treat other conditions can benefit people with Alzheimer’s and other forms of dementia. This approach to research could make it much quicker to get promising new drugs to the people who need them.”

The study used mice that expressed human mutated genes that cause Alzheimer’s. Those genes have been found in people who have a form of Alzheimer’s that can be inherited.

In a maze test, learning and memory formation were much improved by the drug, which also:

  • enhanced  levels of a brain growth factor which protects nerve cell functioning
  • reduced the amount of amyloid plaques in the brain linked with Alzheimer’s
  • reduced both chronic inflammation and oxidative stress
  • slowed down the rate of nerve cell loss

“These very promising outcomes demonstrate the efficacy of these novel multiple receptor drugs that originally were developed to treat type 2 diabetes but have shown consistent neuro-protective effects in several studies,” Prof Holscher said.

“Clinical studies with an older version of this drug type already showed very promising results in people with Alzheimer’s disease or with mood disorders.

“Here we show that a novel triple receptor drug shows promise as a potential treatment for Alzheimer’s but further dose-response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drug is superior to previous ones.”

Type 2 diabetes is a risk factor for Alzheimer’s and has been implicated in the progression of the disease.

Do you currently take diabetes medication? Do you think your memory has improved since you started taking it?

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    COMMENTS

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    Nika
    11th Jan 2018
    10:58am
    Which drug? Yet another broad statement with no clear information.
    Triss
    11th Jan 2018
    1:25pm
    The report I read starts off positive and then backs off at the end.
    Puglet
    11th Jan 2018
    1:07pm
    Nika, the original paper’s authors do not state which drug was used in the study. If you read the study (be warned it’s pretty dense scientific language) you’ll see that they were investigating beta cell agonists’ role in preventing or reducing the effects of Alzheimer’s. It could be any one of a number of drugs all of which are used to manage Type 2 diabetes.
    Mamacrystal
    11th Jan 2018
    1:53pm
    Be good if the drug being talked about was actually named!!
    Good choices
    11th Jan 2018
    2:22pm
    I wonder if there has been a survey done eg. people on Type 2 Diabetes Meds V's people without the Meds, does that mean that people with type 2 diabetes don't get dementia etc.....
    Knows-a-lot
    11th Jan 2018
    2:36pm
    It's often a case of 'use it or lose it'. Keep your brain active! I compose and solve chess problems, as well as writing very complex music.
    musicveg
    11th Jan 2018
    8:57pm
    Just because it works on mice, humans are way different. They just want to sell more drugs for profit. Best cure is prevention and you can even reverse symptoms of diabetes and dementia with a plant based diet. Exercise of the body and brain also of course helps.


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