New hope in treatment of rheumatoid arthritis

Arthritis

When Carol Pocklington was diagnosed with rheumatoid arthritis in 2000, it had a rapid and devastating effect on her health. 

“My knees gave out when I was on holiday … I just thought I had a strained muscle,” Ms Pocklington said.

“I went to my doctor, he took a blood test and it indicated I had chronic rheumatoid arthritis.

“Within a matter of weeks, I was in a wheelchair and couldn’t move … nobody could touch me … I then became virtually bedridden.”

Rheumatoid arthritis, or RA, attacks the joints, causing pain, swelling and loss of function.

Ms Pocklington left her job, and her husband John left his to become her full-time carer.

Lady in wedding dress with Carol in wheelchair
Ms Pocklington (right), pictured at a friend’s wedding, feared she would never walk again after losing function in her knees.(Supplied: Carol Pocklington)

They moved from Sydney to the Sunshine Coast, believing they had little time left.

But shortly after the move, Ms Pocklington met rheumatologist Professor Peter Nash, who encouraged her to take part in a clinical trial of a new arthritis drug.

“And I said absolutely yes, not because I understood it but because I was so desperate,” Ms Pocklington said.

“And that’s really what saved me.”

Man in long sleeve check shirt and woman in black dress on a couch
John and Carol Pocklington now lead an active life, after Ms Pocklington endured a frightening health battle. (ABC Sunshine Coast: Jessica Ross)

Two decades on, Ms Pocklington, now 77, has had two knee replacements but can still walk well.

She still sees Professor Nash.

The rheumatologist said while major advancements had been made in the treatment of RA, there was always an “unmet need” of people who had tried everything and failed to respond.

“And wouldn’t it be nice to get to the root cause … and turn the root cause off, especially early on before things become triggered or established?” he said.

Gut could hold key

Prof. Nash is the principal investigator in a new clinical trial being run by biotherapeutics company Servatus, also based on the Sunshine Coast.

The company has been delving deep into the gut microbiome, which is home to trillions of microbes — including bacteria.

Graphic of girl with gut area highlighted
The gut is home to trillions of microbes, including bacteria that can trigger disease. (Supplied: Servatus)

Some microbes are helpful, but others can be harmful, triggering disease.

Servatus chief executive Wayne Finlayson said they were using a “consortium” of bacteria to treat immune diseases in the trial.

“They’re actually live bacteria common to your immune system and your body,” Dr Finlayson said.

“We’re developing these drugs to modulate the microbiome and rebalance it … other drugs can be quite nasty and the body tolerates them but after a certain amount of time patients have to switch drugs.

“Hopefully, we can provide a much gentler and natural form of treatment.”

Man in science lab smiling at camera
Dr Finlayson says preclinical studies involving animals have shown promising results. (ABC Sunshine Coast: Meg Bolton)

Dr Finlayson said the gut microbiome had been a focus in the scientific community for some time.

“I guess the medical profession is just catching up … everyone’s starting to talk about gut health,” he said.

“The microbiome is really the next evolution in medicine.”

The missing link

The company is looking for more participants, ideally located on or close to the Sunshine Coast, to take part in the trial.

Dr Finlayson hoped the research could determine what triggers the disease, which affects around 456,000 Australians.

“We work with a company in Norway, experts in what’s called biomarkers, and they can look at what people have in their microbiome and say, ‘Well, you may be predisposed to getting this’,” Dr Finlayson said.

Man smiling at camera in doctor's clinic, with computer and model hand
Professor Nash says the trial is exciting because it will help the medical profession understand what causes the condition. (ABC Sunshine Coast: Jessica Ross)

Prof. Nash has been involved in arthritis clinical trials since 1988 and said, while RA could be hereditary, it could also affect anyone.

“We can control it, we can induce remission, we can stop damage, we can control pain, we can improve quality of life,” Prof. Nash said.

“But the next step is doing something about prevention and cure … that’s the big step that’s not here yet.”

Anyone interested in learning more about the clinical study, or to check if they’re eligible to participate, is encouraged to visit the study’s website or call (07) 3130 0820.

 

Written by ABC News

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